There are a wide ranging number of supplements to take with Wegovy that can aid your weight loss journey. Wegovy (semaglutide) works by reducing appetite, increasing fullness and slowing gastric emptying. As a result, many people worry about absorption and timing.
The official product information and clinical data at the treatment dose did not show a clinically meaningful effect on the absorption of most medicines. Even so, individual circumstances vary, so take personalised advice if you’re on important oral medicines.
You don’t have to separate vitamins from your weekly weight loss jab, and you don’t need complicated rules. Focus on feeling well, staying hydrated, and hitting your protein and fibre goals. If a day is rough (nausea, vomiting, diarrhoea), strip things back. Add supplements one at a time so you can tell what actually helps.
Important: If you’re on critical‑dose tablets (e.g., certain anti‑seizure medicines, warfarin, thyroid hormone), ask your prescriber whether any timing separation is sensible for you.
What supplements should I take with Wegovy?
Most people are really asking two things: what’s safe and genuinely helpful, and what’s not worth it. Focus on a few proven basics and keep everything else simple.
| Supplement | Why consider | Typical use | Wegovy note | Avoid if… | Evidence |
|---|---|---|---|---|---|
| Vitamin D | Many UK adults are low in winter; supports bone and muscle function | 10 μg (400 IU) daily Oct–Mar (or year-round if advised) | Simple, safe baseline | High-dose use unless advised | NHS & PHE/NICE winter guidance. (nhs.uk, GOV.UK) |
| Psyllium (soluble fibre) | Helps constipation and fullness | Start 5 g/day, build to 5–10 g/day with water | Increase slowly; hydrate well | Poor fluid intake; acute diarrhoea | RCT meta-analysis finds psyllium effective for constipation. (PMC) |
| Protein (food or powder) | Helps protect lean mass during weight loss; supports satiety | Aim ~1.2–1.6 g/kg/day, spread across meals | Combine with light resistance exercise | Kidney disease: seek medical advice | Reviews/position statements support higher protein during energy deficit. (PMC, PubMed) |
| Creatine monohydrate | Supports strength/performance; may help retain FFM while dieting | 3–5 g/day (no need to “load”) | Hydrate; take any time of day | Known kidney disease: get medical advice | ISSN & reviews support safety/effectiveness at 3–5 g/day. (BioMed Central, GOV.UK) |
| Electrolytes / ORS | Useful if vomiting/diarrhoea causes dehydration | Use pharmacist-advised ORS as directed | Especially helpful on rough GI days | Severe symptoms: seek medical help | NHS advises ORS where dehydration risk exists. (nhs.uk) |
| Magnesium (low-dose, glycinate/citrate) | May help cramps/constipation in some | Start low; consider with food | Citrate/oxide can loosen stools | High-dose use; renal impairment | High doses cause diarrhoea; start low and assess. (nhs.uk, Office of Dietary Supplements) |
| Multivitamin (sensible doses) | Insurance policy if appetite is low | 1× RDA-level daily | Check label for unnecessary stimulants | If contains glucose-lowering herbals, avoid | General NHS vitamin guidance applies. (nhs.uk) |
What genuinely helps on Wegovy (food first, then smart supplements)
You’ll get the biggest benefit from food habits such as adequate protein, plenty of plants, and steady fluids. Supplements simply fill gaps or make side‑effects easier to manage.
Vitamin D: a simple UK baseline
Many adults in the UK are low on vitamin D during autumn and winter. In all the supplements to take on Wegovy, this is probably the most popular. The NHS advises 10 micrograms (400 IU) daily from October to March (some people benefit year‑round). It’s safe, inexpensive, and useful for bone and muscle function while you’re losing weight. There’s no special timing with Wegovy, just take it when you remember.
Good to know: more isn’t better. Stick to the advised dose unless your clinician has checked your level and recommended otherwise.
Bottom line: A low‑dose vitamin D (400 IU) in autumn/winter is a safe, low‑effort baseline; no special timing with Wegovy.
Soluble fibre (psyllium): for constipation and comfortable fullness
Constipation is common when you’re eating less and gastric emptying is slower. Psyllium is a gentle, soluble fibre with strong evidence for constipation relief. Start with ~5 g daily in water and, if needed, work up to 5–10 g. Increase gradually and drink more fluids to avoid bloat. If diarrhoea appears, ease off and re‑introduce later.
Tip: on days you feel nauseous, don’t add extra fibre. Wait until your stomach settles.
Psyllium build‑up plan (example)
| Days | Amount | Notes |
| 1–3 | ~5 g once daily (≈1 tsp) | Mix in water; drink another glass after. |
| 4–7 | ~5 g twice daily or 7–8 g once | Only increase if comfortable. |
| Week 2+ | Up to 10 g/day if needed | Hold or reduce if bloating/loose stools. |
Clinician’s note: With fibre, small and steady wins. Most side‑effects come from increasing too quickly. — Paul John MPharm, IP Clinical Pharmacist Prescriber
Bottom line: Psyllium can ease constipation and support fullness. Start low, go slow, hydrate.
Protein (food or powder): protect your lean mass
Rapid weight loss can cost you muscle if protein is too low. A sensible target during fat loss is ~1.2–1.6 g of protein per kg of body weight per day, split across meals (for example, 25–35 g per meal). Food should do most of the work, but a simple whey or plant protein can help you land the number—especially if appetite is small. Pair this with two or three short resistance sessions a week for best results.
What does that look like?
A day might include eggs or Greek yoghurt at breakfast, a chicken or tofu‑based lunch, fish and veg at dinner, and a shake when appetite is low. No special timing vs. your injection is required.
Protein targets by body weight (daily range)
| Body weight | Target protein |
| 60 kg | 72–96 g |
| 70 kg | 84–112 g |
| 80 kg | 96–128 g |
| 90 kg | 108–144 g |
| 100 kg | 120–160 g |
| 120 kg | 144–192 g |
Clinician’s note: Split protein across the day. Hitting 25–35 g per meal is far easier than chasing a big number at dinner. — Alex Gibbins MPharm, IP Medication Safety Pharmacist
Bottom line: Food first, supplements if needed—aim for 1.2–1.6 g/kg/day and add two or three short resistance sessions.
Creatine monohydrate: small scoop, big payoff for strength
Creatine is a hugely popular supplement irrespective of whether you’re taking Wegovy. If you’re lifting even a little, creatine can help maintain training quality and lean mass while you’re in a deficit. The well‑supported dose is 3–5 g per day (no loading phase needed). Take it any time; consistency matters more than timing. Hydrate well. People with existing kidney disease should seek medical advice before use.
Bottom line: If you resistance train, creatine 3–5 g/day is a simple add that supports performance and lean mass.
Electrolytes / oral rehydration solutions: for ‘rough’ GI days
If you’ve had vomiting or diarrhoea, a pharmacist‑recommended oral rehydration solution (ORS) can be a fast, simple fix for fluid and electrolyte replacement. Use as directed; this isn’t a daily supplement for most people—it’s a tool for when you need it.
Bottom line: Keep ORS for dehydration days—use what your pharmacist recommends; you don’t need it routinely.
Magnesium (choose form, start low)
Some people find magnesium glycinate or magnesium citrate helps with cramps or constipation. Start low and take with food. Be aware that higher doses, especially magnesium oxide or large citrate doses can loosen stools. If diarrhoea appears, reduce the dose or try a different form. If you have kidney problems, seek advice before use.
Magnesium forms at a glance
| Form | GI tolerance | Typical use note | Wegovy-specific tip |
| Glycinate | Gentler on stomach | General relaxation/sleep | Start low at night if drowsy |
| Citrate | Moderate; can loosen stools | Constipation relief | Avoid on diarrhoea days |
| Oxide | Most likely to loosen stools | Budget options | Usually not ideal if bowels are sensitive |
Multivitamin (sensible doses only)
A standard, RDA‑level multivitamin is fine if your appetite is small for a while. Avoid products spiked with stimulants or weight‑loss claims. If the label lists glucose‑lowering herbals (see below), pick a simpler formula. An RDA‑level multivitamin is optional insurance while appetite is low—skip formulas with stimulants or glucose‑lowering herbals.
What supplements should I avoid taking on Semaglutide (Wegovy)?
A small set are better skipped or used only with clinical advice, because they can amplify side‑effects, interact with medicines, or push blood sugar too low. In practice, that means steering clear of stimulant ‘fat‑burner’ mixes and being cautious with glucose‑lowering herbals such as chromium and berberine.
Not everything labelled “natural” is harmless, and not every “metabolism” product is helpful alongside a GLP‑1 medicine. These are the main troublemakers:
- Unregulated weight‑loss stacks: UK regulators regularly warn about unsafe products sold online or via social media. Stimulants can worsen nausea, raise heart rate, disrupt sleep and add nothing to semaglutide’s mechanism. Give them a miss.
Chromium
Evidence for weight loss is weak, and chromium can enhance insulin sensitivity. In people using antidiabetic medicines, that can increase the risk of low blood sugar. Unless your clinician recommends it for a specific reason, avoid it.
Berberine
Often marketed as ‘nature’s Ozempic,’ berberine lowers glucose and interacts with drug‑metabolising enzymes and transporters (CYPs/P‑gp). That means real interaction potential and unpredictable effects. Avoid unless your prescriber explicitly says otherwise.
Herbal blends
Quality varies widely, labels can be incomplete, and ingredients can interact with prescription drugs. If you’re set on a particular herbal, run it past a pharmacist first.
Do supplements need to be separated from your Wegovy injection?
Short answer: no.
There’s no convincing evidence on supplements to take on Wegovy that taking vitamins or minerals at a particular time relative to your weekly jab changes outcomes. The official medicine information acknowledges that GLP‑1 receptor agonists slow gastric emptying, but trials at the treatment dose did not find a clinically relevant impact on the absorption of most oral medicines.
Where timing can matter is for tolerability. On a day when your stomach feels delicate, keep it simple: avoid starting a new fibre, hold off on high‑dose magnesium, and focus on hydration and protein once nausea eases. If you do take critical‑dose tablets, your prescriber may suggest spacing those medicines from large fibre doses or reviewing the plan altogether—ask for personalised advice.
Constipation plan
Think fluids first, then soluble fibre (psyllium), then small, regular movement. Build fibre slowly and don’t add new products on a bad‑nausea day. If you’re still stuck after a week of trying, speak to a pharmacist—there are simple over‑the‑counter options they can tailor to you.
Nausea day plan
Strip back to the basics: sips of fluid, bland foods in small portions, ORS if you’re dehydrated, and simple protein once you can manage it again. Pause non‑essentials and reintroduce one at a time.
Plateau plan
Don’t chase exotic supplements. Re‑check the fundamentals: protein target, fibre, steps, and two short resistance sessions per week. Most plateaus are lifestyle, not micronutrient, problems.
Should I worry about interactions and absorption?
It’s sensible to be aware, not anxious. The mechanism of semaglutide suggests slower stomach emptying, which could theoretically alter the time to peak for some tablets. In practice, clinically meaningful problems are uncommon, and large trials at the obesity dose did not show a broad, clinically relevant impact on the absorption of most medicines.
If you take medicines where small changes matter (for example, warfarin, levothyroxine, certain anti‑epileptics), ask your prescriber whether any monitoring or spacing is appropriate for you.
Food first: a simple pattern that works with Wegovy
- Protein: aim for ~1.2–1.6 g/kg/day, split across 3–4 eating occasions. Build meals around lean meat, fish, eggs, dairy, tofu/tempeh, lentils, or a shake when it’s hard to eat much.
- Plants: target colour and fibre—vegetables, fruit, legumes, oats, wholegrains, nuts and seeds. If appetite is tiny, prioritise protein first and layer plants as tolerated.
- Fluids: carry a bottle; include broths or herbal teas if plain water is unappealing. Use ORS only when you’re actually dehydrated.
- Movement: two or three brief resistance sessions per week and light daily movement help protect lean mass and keep you feeling capable.
Common questions around supplements to take on Wegovy
Can I take creatine on Wegovy?
Yes. For most healthy adults, 3–5 g/day of creatine monohydrate is safe, well‑studied and useful for strength. Hydrate well. If you have kidney disease, seek medical advice first.
Is taking magnesium supplements with Wegovy okay?
Usually, yes, as long as you start low and choose a gentler form such as glycinate. Magnesium oxide and large citrate doses can loosen stools. If diarrhoea appears, reduce the dose or switch forms.
Do I need a multivitamin?
Not if you’re eating well, but an RDA‑level multivitamin is fine during the early appetite‑suppressed weeks. Check labels and avoid formulas spiked with stimulants or glucose‑lowering herbals.
Should I take berberine with semaglutide?
No, unless your prescriber specifically recommends it. Berberine lowers glucose and has interaction potential.
What about vitamin D?
In the UK, adults are advised to consider 10 micrograms (400 IU) daily in autumn/winter. Many people continue year‑round if advised by a clinician.
Do electrolytes help with Wegovy side‑effects?
They can if you’re dehydrated from vomiting or diarrhoea. Ask a pharmacist which oral rehydration solution is right for you and how much to use.
Is there a best time to take supplements on Wegovy injection day?
Not really. There’s no good evidence that timing vitamins around your jab changes outcomes. Prioritise what you can tolerate and keep new products off the agenda on a queasy day.
Can I take collagen with Wegovy?
Collagen is simply a protein source. It’s fine to use if you like it, but it’s not a magic bullet. You can count it towards your daily protein target and prioritise whole‑food protein first.
Can I take probiotics on Wegovy?
Generally safe for most people; some find they help with GI comfort, though evidence is mixed. Choose a reputable brand. If you’re immunocompromised or have complex medical conditions, check with your clinician first.
Is vitamin B12, iron or zinc okay with Wegovy?
Yes. B12 is well‑tolerated. Iron can upset the stomach—take with food and consider separating from large fibre doses. Zinc is fine in sensible amounts; don’t exceed high‑dose products without advice.
Safety, regulation and good sense (UK)
- Buy medicines from regulated UK providers The MHRA has repeatedly warned about unsafe, counterfeit or unlicensed weight‑loss products sold online or via social media.
- “Natural” does not mean “interaction‑free.” Herbal products can interfere with prescribed medicines. Tell your pharmacist what you’re taking.
- If side‑effects are severe or persistent, contact your prescriber promptly.
How we wrote this guide to supplements to take with Wegovy
Authored by a clinical pharmacist and medically reviewed by a prescriber, this page summarises UK‑relevant guidance and high‑quality reviews in regard to supplements to take on Wegovy. Lotus medical staff reference authoritative sources (EMC/SmPC, EMA/EPAR, NHS guidance) and peer‑reviewed position statements, and the page is updated as guidance evolves.
References
- EMA/EPAR: Wegovy (semaglutide) – efficacy, safety and pharmacology; gastric emptying and interactions summary.
- Electronic Medicines Compendium (EMC), UK: Wegovy (semaglutide) SmPC – dosage, warnings, interactions.
- NHS: Vitamin D – advice for adults in the UK; 10 micrograms (400 IU) daily in autumn/winter.
- Soluble fibre (psyllium) for constipation – systematic reviews and RCT meta‑analyses supporting efficacy and tolerability.
- Protein during weight loss – reviews and consensus statements supporting ~1.2–1.6 g/kg/day to help preserve lean mass.
- Resistance training with higher protein intake – evidence synthesis for muscle retention during energy deficit.
- International Society of Sports Nutrition position stand: creatine monohydrate – safety and dosing (3–5 g/day).
- Narrative and systematic reviews on creatine for muscle function and lean mass maintenance during dieting.
- NHS guidance on oral rehydration solutions (ORS) for dehydration related to vomiting/diarrhoea.
- NHS and clinical reviews on magnesium supplementation forms, GI effects and safety considerations.
- MHRA safety communications on illegal/unsafe weight‑loss products sold online and via social media.
- UK media and MHRA public warnings regarding counterfeit weight‑loss injections and unregulated products.
- NIH Office of Dietary Supplements – Chromium Fact Sheet for Health Professionals: efficacy and hypoglycaemia risk with antidiabetic medicines.
- Reviews on berberine’s glucose‑lowering effects and potential CYP/P‑gp interactions.
- Pharmacology reviews of berberine: mechanisms, drug–drug interaction potential and safety profile.
Useful links
- https://www.ema.europa.eu/en/medicines/human/EPAR/wegovy
- https://www.medicines.org.uk/emc/product/13799/smpc
- https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9535527/
- https://pubmed.ncbi.nlm.nih.gov/28698222/
- https://www.sportsnutritionsociety.org/PDFuploads/ISSN-PDF-Upload-394.pdf
- https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0173-z
- https://www.nhs.uk/conditions/dehydration/
- https://www.nhs.uk/conditions/vitamins-and-minerals/others/
- https://www.gov.uk/government/news/mhra-warns-of-unsafe-fake-weight-loss-pens
- https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.762654/full
- https://www.nhs.uk/tests-and-treatments/herbal-medicines/
