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Mounjaro maintenance
Written by: James Reynolds – MPharm, DipClinPh, PgCert Derm, SCOPE, IP
You’ve worked hard to reach this point. Mounjaro maintenance means keeping the weight off without turning your life upside down. This page covers the dose you’ll likely remain on, what to try if appetite or your weight start to creep, how to handle travel and busy weeks, and when to contact Lotus Weight Loss.
Aims of maintenance: Stay on the lowest effective weekly dose of Mounjaro that keeps weight stable and appetite manageable, with side‑effects you can live with. We’ll review regularly and adjust if life changes.
Not sure what to do? Message the clinic and let a prescriber help.
Most people maintain their weight on 5-15mg once weekly. We cannot exceed 15 mg on Mounjaro. Use this table as a guide.
| Weekly dose | When we use it | What to watch | Likely next step |
| 5mg | Appetite settled and weight steady on a lower dose. | Hunger building, evening snacking, or 2-3kg up in 4-8 weeks. | Consider 10mg, then clinic review in 4-8 weeks. |
| 10mg | 5mg wasn’t enough. | Some GI effects in a minority. | If still hungry, consider 15mg; if well controlled with annoying side‑effects, trial 5mg with review. |
| 15mg | Needed for control when lower doses failed. | More GI susceptibility for some. | If steady for 8-12 weeks but side‑effects bother you, consider 10mg and reassess. |
| Other licensed doses (2.5mg, 7.5mg or 12.5mg) can be prescribed if you feel this is what works best for you personally. | |||
Note: At lower BMIs we keep a light touch. We won’t increase dose below a healthy BMI unless there’s a clear clinical reason we agree together.
When on Mounjaro maintenance look at your weight trends, not just a single weigh‑in. If you’re 2-3kg up across a month or two, or clothes tighten and hunger feels loud most days, treat that as your early warning.
For one week, do the basics well. Eat three meals. Add a palm of protein each time. Go heavier on veg and fibre. Keep water close. Add 2,000 steps above your usual routine. Keep a steady bedtime. On day eight, take stock. If your weight is still climbing message the clinic and we’ll adjust your plan together.
Maintenance rests on a few easy wins.
Those being:
Small, boring habits do most of the heavy lifting during Mounjaro maintenance. Medication supports them; it doesn’t replace them. If you’re peri‑ or post‑menopausal, or your cycle shifts appetite, tell us so we can pace reviews and targets accordingly.
Keep pens in hand luggage. If the pen is in use you can keep it at room temperature below 30 °C. In hot weather use a small medication cooler.
Don’t arrive starving. Eat normally through the day. Start with protein and veg, enjoy what you fancy, and move on. The next day, return to normal. No ‘punishment’ routines.
Set two easy wins: a simple breakfast (e.g., yoghurt with berries and oats, or eggs on toast) and a 10‑minute walk after lunch. Tiny habits will keep you steady.
Eat first, set a limit upfront, and alternate with water. The goal isn’t perfection; it’s staying in charge.
Tirzepatide (Mounjaro) slows stomach emptying. Most everyday medicines are fine, but if you take drugs that need tight monitoring (e.g., Warfarin), your prescriber may check levels as usual.
If you have type 2 diabetes, hypo risk is mainly an issue with insulin or sulfonylureas. These often need reducing when appetite and glucose improve. Expect closer glucose / A1c monitoring during dose changes.
Always tell your surgical / anaesthetic team that you use a GLP‑1/GIP medicine. Do not stop unless advised as plans are personalised.
On the NHS, Tirzepatide (Mounjaro) is used within specialist services under defined criteria, with a 6‑month review of weight response at the highest tolerated dose. In private care we follow the same evidence and safety guidance, reviewing you regularly with clear goals. Either way, the plan is safe, monitored and tailored to your life.
Many people regain some weight after stopping—this is biology, not failure. If you plan a break, keep the easy habits (protein, fibre, steps, sleep) and book a follow‑up in 4-8 weeks. If your weight rises and keeps going, we can talk about restarting or other options.
When to act: If hunger is 6+ most days for two weeks, or your weight trend rises for four weeks, tighten the basics for a week. If it doesn’t settle, contact the clinic to review your plan or dose.
Common questions
Not necessarily. Mounjaro maintenance isn’t a life sentence; it’s a period of keeping results steady on the lightest touch that works. Many patients taper down over time; others need longer support. We’ll help you adapt as life changes.
Check basics for a fortnight such as protein at meals, sleep, steps, alcohol. If hunger stays loud or weight creeps despite doing the basics, contact the clinic. We’ll look for triggers (stress, medicines, cycle) and discuss your options.
Always tell the team you’re on Tirzepatide. Don’t stop unless advised. Plans are individualised to balance aspiration risk and overall safety.
Weight often rebounds without strong lifestyle support. We can plan a deliberate step‑down or pause and review at 4-8 weeks.
—James Reynolds
Lead Clinical Pharmacist, Lotus Weight Loss Clinic
James is a UK-registered pharmacist with over 15 years’ experience in NHS and private healthcare. He specialises in weight management and GLP-1 prescribing, and holds SCOPE certification in obesity care — a globally recognised standard for evidence-based treatment. More about James
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