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Mounjaro vs. Ozempic: Which GLP-1 medication could be right for you?




Written by:
<br:


James Reynolds
MPharm | SCOPE


Lead Pharmacist</br:

"Are you torn between Mounjaro and Ozempic to help manage your weight or type 2 diabetes? Both of these GLP-1 medications are designed to regulate blood sugar and support significant weight loss. In this blog, we’ll explore the differences, benefits, and potential drawbacks of each, so you can make an informed decision."
Watercolor-style image showcasing Mounjaro and Ozempic medication vials side by side.

💡Key takeaways 

 

1️⃣ Dual vs. Single Receptor Action: Mounjaro (tirzepatide) acts on both GLP-1 and GIP receptors, whereas Ozempic (semaglutide) targets only GLP-1.

2️⃣ Weight Loss Comparisons: Studies show Mounjaro may yield greater overall weight loss than Ozempic, but individual results vary.

3️⃣ Common Side Effects: Both can cause gastrointestinal symptoms (nausea, vomiting, etc.), and each carries a boxed warning related to potential thyroid tumour.

4️⃣ Cost and Availability: Mounjaro can be pricier and less accessible. Ozempic (semaglutide) is more widely prescribed in the USA, though often used off-label for weight loss in the UK. Wegovy is also another brand of semaglutide more commonly used in the UK for weight loss.

5️⃣ Individual Factors Matter: Your unique medical history and health goals ultimately shape which medication is best for you. If you like, you can contact a Lotus pharmacist to discuss in more detail.

Unpacking GLP-1 medications—a closer look

 

GLP-1 pens collection Mounjaro Wegovy Ozempic Zepbound

GLP-1 (glucagon-like peptide-1) medications, commonly referred to as weight loss injections or slimming injections in some contexts, are transforming how we address weight and type 2 diabetes management. The term “GLP-1” actually describes a class of drugs (GLP-1 receptor agonists) designed to mimic a hormone in the body that helps regulate blood sugar and appetite.

Understanding GLP-1’s role

GLP-1 receptor agonists stimulate insulin production when your body’s glucose levels rise, slow down the digestion process, and make you feel fuller sooner. These effects can be powerful for individuals with type 2 diabetes and those seeking sustained weight loss results. Ozempic, Wegovy, Saxenda, and Mounjaro belong to this broader category of treatments. However, Mounjaro stands out because it targets not just GLP-1 receptors but also GIP (glucose-dependent insulinotropic polypeptide) receptors—essentially doubling down on the body’s natural glucose-control systems.

Mounjaro vs. Ozempic in a nutshell

  1. Mounjaro (Tirzepatide)
    • Dual Action: Targets both GLP-1 and GIP receptors.
    • Primary Benefits: Impressive blood sugar control, potentially higher average weight loss.
    • Considerations: May cause more pronounced gastrointestinal side effects; often higher in price.

       

  2. Ozempic (Semaglutide)
    • Single Receptor: Targets only GLP-1.
    • Primary Benefits: Good balance between efficacy and tolerability, widely prescribed.
    • Considerations: Not as comprehensive in mechanism as Mounjaro; may deliver slightly less weight reduction overall.


As an online weight loss clinic operating in the UK, we often hear from clients who are curious about these newer
GLP1drugs. If you’re interested in learning more about other available treatments, explore our Treatments page to see how these medications fit into a broader weight loss program.

Comparing effectiveness, side effects, and practical considerations

A graphic showing GLP-1 medication side effects

Effectiveness for Weight Loss and Diabetes Management

  • Weight Loss: Clinical studies have found that Mounjaro leads to an average of 15.3% total weight loss after one year, compared to roughly 8.3% with Ozempic. Over a longer term (72 weeks), Mounjaro participants often see around 20% average weight reduction, whereas Ozempic users may see closer to 15%.

  • Blood Sugar Control: Both medications effectively lower HbA1c levels, crucial for managing type 2 diabetes. Mounjaro’s dual-receptor mechanism has shown slightly greater reductions in blood sugar markers than Ozempic.

When it comes to Mounjaro weight loss outcomes, many individuals experience significant progress in reducing body mass and improving metabolic markers. However, semaglutide weight loss—as seen with Ozempic—also remains a highly reputable option, especially for those who might be more sensitive to medication side effects.

Potential Side Effects

Both drugs may trigger gastrointestinal effects:

  • Nausea, Vomiting, Diarrhea, and Abdominal Pain: These symptoms are relatively common with any GLP-1 medication.

  • Dual Receptor Intensification (Mounjaro): Because Mounjaro targets two receptors, its GI side effects can be more pronounced for some people.

  • Thyroid Cancer Risk: Both medications carry a boxed warning for potential thyroid tumours observed in animal studies.


Remember, side effects vary and depend on your personal tolerance. Speak with a healthcare professional if you’re experiencing discomfort or have a history of thyroid disease.

Cost, Coverage, and Availability

  • Mounjaro: Tends to be pricier and less widely available. In some cases, insurance or health plans may not cover it as readily.

  • Ozempic: Typically has broader coverage thanks to its established role in diabetes care. Many UK-based individuals who seek Ozempic for weight loss find they also appreciate its familiarity within the healthcare system.

If cost is a primary concern, take a look at our Medications and Pricing page to explore all your options. There, you’ll see cost breakdowns and coverage details that may guide your choice.

Regulatory Approvals and Off-Label Use

  • Mounjaro: Approved for both type 2 diabetes management and chronic weight management in certain regions.

  • Ozempic/Wegovy: Ozempic is usually approved for diabetes, while Wegovy (a higher-dose version of semaglutide) is specifically approved for weight management.

Some individuals use Ozempic off-label for weight loss. Before doing so, always consult a medical professional to determine if this approach suits your needs and health history.

Finding the right treatment path—Practical tips

Watercolor-style image showing a path, symbolising the direction and journey associated with weight loss treatment

Whether you’re battling type 2 diabetes, looking to accelerate fat loss, or simply aiming to optimize your health, choosing between Mounjaro and Ozempic often boils down to several practical factors. Below are some tips to help guide you:

  1. Assess Your Health History
    • Talk with your healthcare provider about any pre-existing conditions, especially thyroid issues, gastrointestinal disorders, or a history of pancreatitis. Every medication carries its own risk-benefit profile.

       

  2. Consider Your Budget and Access
    • Medications like Mounjaro can be more expensive. Budget for ongoing treatments.

       

  3. Track Your Progress
    • GLP-1 medications require consistent use and monitoring. Keep a journal of your side effects, weight changes, and overall health markers to discuss with your doctor. Regular check-ups and honest feedback will help fine-tune your regimen.

       

  4. Utilise Available Resources
    • Leverage weight loss injections responsibly and pair them with dietary changes, exercise routines, and regular consultations. Check out our Thinking of Starting? page for details on how to begin a medically supervised program.

       

  5. Stay Informed
    • Research is ongoing. We see frequent updates on new guidelines, supply considerations, and potential approvals. Stay up-to-date with our News & Insights to learn about the evolving landscape of medications like Mounjaro, Wegovy, and others.


If you decide to switch medications or want to compare them side by side, we also offer resources to help you
Switch Supplier easily and with minimal disruption to your current plan.

Weight loss injection pens.

Conclusion

When it comes to GLP1 therapies, no single medication is universally “best.” Mounjaro offers a dual-receptor approach that can deliver remarkable blood sugar control and weight loss—but often at a higher price and potentially with more pronounced side effects. Ozempic provides a more established single-receptor option that still yields notable results. Ultimately, your decision should hinge on consultation with a qualified medical professional, careful consideration of any underlying health conditions, and your personal goals for weight loss and metabolic management.

For more insights, or if you’re ready to begin a program tailored to your unique needs, Contact Us to learn how we can support you every step of the way. Remember, whether you choose Mounjaro or Ozempic, a well-rounded strategy that combines medical guidance, dietary habits, and consistent follow-up is the key to a healthier future.

Frequently Asked Questions

Is Mounjaro more effective than Ozempic for weight loss?

Mounjaro often yields higher average weight loss compared to Ozempic. However, individual responses vary, so consulting a healthcare professional is crucial.

Does Mounjaro cause more side effects than Ozempic?

Mounjaro can cause more pronounced gastrointestinal symptoms (e.g., nausea or vomiting) because it works on dual receptors (GLP-1 and GIP). Still, side effects differ from person to person.

Can I use Ozempic purely for weight loss?

While primarily approved for type 2 diabetes, Ozempic is sometimes prescribed off-label for weight loss. Wegovy is a higher-dose variant of semaglutide specifically approved for obesity management.

Is one of these medications cheaper than the other?

Generally, Ozempic tends to be less expensive and more widely covered than Mounjaro. Check our Medications and Pricing page for more details on current costs.

How do I decide which medication is right for me?

Consider your health profile, potential side effects, and budget. Speak with your healthcare provider for individualised advice. You can also learn more by exploring our resources on Thinking of Starting?

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