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Will I regain weight once I stop taking Mounjaro or Wegovy?




Written by:
<br:


James Reynolds
MPharm | SCOPE


Lead Pharmacist</br:

"Wondering if you’ll regain weight after stopping Mounjaro (tirzepatide) or Wegovy (semaglutide)? Yes, weight regain is common, but it isn’t unavoidable. By adopting sustainable habits—nutrient-rich meals, regular exercise, and behavioral strategies—you can reduce rebound weight and maintain long-term success, ensuring these groundbreaking injections aren’t just a temporary fix for obesity."
A winding path leading through a green landscape, symbolising a long-term health journey.

💡Key Takeaways 

1️⃣ Weight Regain is Common, But Not Inevitable: Many people regain some weight after stopping Mounjaro or Wegovy, yet proper planning can minimise this rebound. See the section below for the percentage weight regain from the key clinical trials.

2️⃣ Hormonal & Metabolic Changes Drive Regain: Hunger hormones and slowed metabolism kick in once medication is discontinued.

3️⃣ Lifestyle Habits Are Critical: Balanced nutrition, regular exercise, and stress management significantly reduce the likelihood of regaining weight.

4️⃣ Gradual Tapering Helps: Slowly phasing out your medication under medical supervision may ease the transition and reduce rebound weight gain.

5️⃣ Long-Term Support Is Essential: Ongoing support programs, including nutritional and psychological guidance, can help maintain weight loss over time.

Why Weight Regain Happens After Stopping Mounjaro or Wegovy


Hormonal and Metabolic Adaptations

When using Mounjaro or Wegovy, your body undergoes powerful changes. These medications work by activating the GLP-1 (and in Mounjaro’s case, also GIP) receptors, which reduce appetite, slow digestion, and improve insulin sensitivity. When you stop taking them, those effects gradually wear off.

  • Appetite hormone rebound occurs. Hunger-regulating hormones such as ghrelin surge, increasing cravings and caloric intake.

  • Slowed metabolism—a natural consequence of weight loss—makes it easier to regain weight, even if you’re eating the same as before.

  • Body composition shifts: The weight regained is often more fat than muscle, especially if muscle wasn’t preserved during weight loss.

Lifestyle Factors

Biology is just one part of the picture. Behavioural patterns during and after treatment can either support or sabotage your progress.

  • Poor diet quality, especially ultra-processed foods, accelerates weight rebound.

  • Physical inactivity means reduced calorie burn and muscle loss.

  • Emotional eating and unmanaged stress often re-emerge post-treatment if not addressed.
A graph showing Mounjaro versus Wegovy in terms of weight loss and weight regain.

What the Science Says About Weight Regain


Mounjaro (Tirzepatide)

In a major 88-week clinical trial, participants who discontinued tirzepatide after 36 weeks regained an average of 11.5% of the weight they had lost at the 88 week mark. Conversely, those who continued the medication lost an additional 5% over the next 52 weeks.

Wegovy (Semaglutide)

For Wegovy users, the story is even more striking. Studies show that up to two-thirds of the weight lost is regained within a year of stopping the medication.

Woman with a healthy lifestyle : representing food, exercise, and mental wellness.

Strategies to Prevent Weight Regain

1. Transition to Sustainable Habits

Weight loss medications provide a powerful jumpstart, but long-term success depends on embedding lasting habits.

  • Diet: Emphasise whole foods—think lean proteins, fibre-rich vegetables, healthy fats, and fewer processed items.
  • Exercise: Aim for 150 minutes of cardio per week plus 2–3 resistance sessions to maintain muscle.
  • Mindset: Cognitive behavioural therapy or mindfulness practices can help address triggers like stress or boredom eating.

     

2. Taper Off Medication—Don’t Go Cold Turkey

A slow, supervised reduction in dosage may help your body adapt more gradually, giving you time to implement lifestyle changes before the medication’s effects wear off. Learn more about tapering approaches from EASO.

3. Get Long-Term Support

Structured weight management programmes that combine nutrition coaching, fitness planning, and psychological support are proven to help maintain weight loss after stopping GLP-1s.

Weight loss injection pens.

Conclusion

Stopping Mounjaro or Wegovy doesn’t mean your weight loss journey is over—but it does mark the beginning of a new phase. While weight regain is common, it’s not guaranteed. The key lies in using your time on medication to build habits that support long-term health.

Obesity is a chronic condition, and like any long-term illness, it often requires ongoing management. For some, that may mean staying on medication longer. For others, it means doubling down on lifestyle strategies.

But whatever your path, you’re not alone—and you can stay in control.

👉 Start a consultation today to find out if Mounjaro is right for your goals.

Frequently Asked Questions (FAQs)


Will I gain back all the weight after stopping Mounjaro or Wegovy?

Not necessarily. While many people regain some weight, adopting long-term lifestyle changes can significantly reduce regain.

How long does it take to regain weight after stopping the medication?
Most regain happens within 6–12 months, with the bulk occurring in the first year.

Can I stop taking the medication gradually?
Yes. Tapering off under medical supervision can help your body adjust and may lessen the chances of rapid regain.

What are the best ways to keep weight off after stopping GLP-1 medications?

Focus on high-protein, whole-food diets, regular exercise, and psychological support.

Is it safe to go back on the medication if I regain weight?

In many cases, yes—restarting treatment may be appropriate. Speak with your healthcare provider for personalised advice.

Lotus Weight Loss Clinic

Written by:

James Reynolds | MPharm, SCOPE, IP
Lead Pharmacist

Lotus Weight Loss Clinic

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